SGLT-2 Inhibitors and Regenerative Cell Exhaustion
نویسندگان
چکیده
منابع مشابه
SGLT-2 Inhibitors: A New Mechanism for Glycemic Control.
Glucosuria, the presence of glucose in the urine, has long been regarded as a consequence of uncontrolled diabetes. However, glucose excretion can be induced by blocking the activity of the renal sodium-glucose cotransporter 2 (SGLT-2). This mechanism corrects hyperglycemia independently of insulin. This article provides an overview of the paradigm shift that triggered the development of the SG...
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Human Na(+)-D-glucose cotransporter (hSGLT) inhibitors constitute the newest class of diabetes drugs, blocking up to 50% of renal glucose reabsorption in vivo. These drugs have potential for widespread use in the diabetes epidemic, but how they work at a molecular level is poorly understood. Here, we use electrophysiological methods to assess how they block Na(+)-D-glucose cotransporter SGLT1 a...
متن کاملSGLT-2 inhibitors as second-line therapy in type 2 diabetes.
Despite the development of several pharmacological agents over the past decade, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and sodium glucose cotransporter 2 (SGLT2) inhibitors, the management of hyperglycaemia in patients with type 2 diabetes remains challenging. SGLT2 inhibitors are a new class of glucose-lowering agents that have a u...
متن کاملUse of SGLT-2 inhibitors in the treatment of type 2 diabetes mellitus.
INTRODUCTION Diabetes mellitus is one of the most common chronic diseases in the world, with high morbidity and mortality rates, resulting in a greatly negative socioeconomic impact. Although there are several classes of oral antidiabetic agents, most of the patients are outside the therapeutic goal range. OBJECTIVE To review the use of SGLT-2 inhibitors in the treatment of type 2 diabetes me...
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INTRODUCTION For people with type 2 diabetes (T2DM) inadequately controlled with oral antidiabetic drugs (OADs), evidence from both randomized controlled trials (RCTs) and real-world studies has demonstrated that treatment intensification with liraglutide offers effective glycemic control, weight reduction, and a lower risk of hypoglycemia compared to treatment intensification with insulin or a...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2020
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2020.04.003